The influence of chronic renal failure on drug metabolism and transport.

Abstract

Chronic renal failure (CRF) has been shown, in animal models and clinical studies, to significantly reduce nonrenal clearance and to alter the bioavailability of predominantly metabolized drugs. Phase II reactions and drug transporters such as P-glycoprotein (P-gp) and organic anion transporting polypeptide (OATP) are also affected. High levels of… (More)
DOI: 10.1038/clpt.2009.163

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Cite this paper

@article{Dreisbach2009TheIO, title={The influence of chronic renal failure on drug metabolism and transport.}, author={Albert W Dreisbach}, journal={Clinical pharmacology and therapeutics}, year={2009}, volume={86 5}, pages={553-6} }