The influence of cholesterol and lipid metabolism on host cell structure and hepatitis C virus replication.

@article{Sagan2006TheIO,
  title={The influence of cholesterol and lipid metabolism on host cell structure and hepatitis C virus replication.},
  author={Selena M Sagan and Yanouchka Rouleau and Cynthia Leggiadro and Lubica Supekova and Peter G. Schultz and Andrew I. Su and John Paul Pezacki},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  year={2006},
  volume={84 1},
  pages={67-79}
}
The hepatitis C virus (HCV) replicates on a membrane protein complex composed of viral proteins, replicating RNA, and altered cellular membranes. Small-molecule inhibitors of cellular lipid-cholesterol metabolism such as 25-hydroxycholesterol, cerulenin, lovastatin, and GGTI-286 all show a negative effect on HCV replication. Perturbation of host cell lipid and cholesterol metabolism can disrupt replication complexes by altering membranous structures where replication occurs. Changes in… CONTINUE READING