The influence of chlorpropamide pre-treatment on insulin and growth hormone release after arginine.

@article{Riggs1967TheIO,
  title={The influence of chlorpropamide pre-treatment on insulin and growth hormone release after arginine.},
  author={Lorrin A. Riggs and David L. Rabinowitz and Thomas J. Merimee},
  journal={Postgraduate Medical Journal},
  year={1967},
  volume={43},
  pages={458 - 461}
}
  • Lorrin A. Riggs, David L. Rabinowitz, Thomas J. Merimee
  • Published 1967
  • Chemistry, Medicine
  • Postgraduate Medical Journal
  • THE hypoglycaemic effect of the sulphonylurea family of drugs was long suspected to be secondary to endogenous insulin release from the pancreatic islets. This was confirmed by Yalow et al. (1960) who showed a rise in peripheral plasma concentration of insulin after tolbutamide administration to normal subjects. More recently, Coore & Randle (1964) showed that, when isolated segments of rabbit pancreas were incubated in the presence of tolbutamide, there was additional release of insulin into… CONTINUE READING

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