• Biology, Medicine
  • Published in Journal of immunology 1990

The influence of calcium, sodium, and the Na+/Ca2+ antiport on susceptibility to cytolysin/perforin-mediated cytolysis.

@article{Kraut1990TheIO,
  title={The influence of calcium, sodium, and the Na+/Ca2+ antiport on susceptibility to cytolysin/perforin-mediated cytolysis.},
  author={Radim Kraut and Debashish Bose and Edward J. Cragoe and Arnold H. Greenberg},
  journal={Journal of immunology},
  year={1990},
  volume={144 9},
  pages={
          3498-505
        }
}
In NK cell-mediated cytolysis, the degranulation of the NK cell, and the binding and polymerization of its effector molecule cytolysin/perforin, are Ca2+ dependent. To determine if increases in the target cell free intracellular Ca2+ concentration ([Ca2+]i) are also important for cytotoxicity, we examined the effects of Ca2+ substitutes, promotors of Ca2+ influx; and inhibitors of Ca2+ efflux on the cytolysis mediated by purified cytolysin. Ca2+ promoted cytolysin-mediated cytolysis but could… CONTINUE READING