The influence of biodegradable magnesium alloys on the osteogenic differentiation of human mesenchymal stem cells.

@article{Li2014TheIO,
  title={The influence of biodegradable magnesium alloys on the osteogenic differentiation of human mesenchymal stem cells.},
  author={Rachel W. Li and Nicholas T Kirkland and John N. Truong and Jian Wang and Paul N. Smith and Nick Birbilis and David R Nisbet},
  journal={Journal of biomedical materials research. Part A},
  year={2014},
  volume={102 12},
  pages={4346-57}
}
The postdegradation effect of pure Mg, Mg-1Y, Mg-5Al, and Mg-2Ca alloys on the differentiation, proliferation and gene expression of human mesenchymal stem cells (hMSCs) was investigated. It was revealed that that Mg(2+) ions result in an increase in cell proliferation. However, we observed a maximum concentration (approximately 8.0 × 10(-4) M) that was favourable to ATP production, above which ATP production began to decrease. In contrast to proliferation, no maximum concentration for… CONTINUE READING