The influence of beta-adrenoceptor blocking drugs with and without intrinsic sympathomimetic activity on the hormonal responses to hypo- and hyperglycaemia.

@article{Schlter1982TheIO,
  title={The influence of beta-adrenoceptor blocking drugs with and without intrinsic sympathomimetic activity on the hormonal responses to hypo- and hyperglycaemia.},
  author={K. J. Schl{\"u}ter and Walter H. Aellig and K. G. Petersen and H C Rieband and Adolf Wehrli and Lothar Kerp},
  journal={British journal of clinical pharmacology},
  year={1982},
  volume={13 Suppl 2},
  pages={
          407S-417S
        }
}
1 The effects of oral doses of pindolol (15 mg), metoprolol (200 mg) and propranolol (160 mg) on the response to insulin-induced hypoglycaemia and an oral glucose load were investigated. 2 Serum insulin and serum C-peptide secretion in response to a glucose load were inhibited (2P less than 0.01) by metoprolol and propranolol but not by pindolol. 3 During hypoglycaemia metoprolol and propranolol inhibited the clearance of insulin (2P less than 0.01) and caused a delay of glucose nadirs. 4… 
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21 Citations

Beta-adrenoceptor blockade and hypoglycaemia. A randomised, double-blind, placebo controlled comparison of metoprolol CR, atenolol and propranolol LA in normal subjects.
TLDR
It is concluded that beta-adrenoceptor antagonists modify the physiological and hormonal responses to, but do not adversely affect awareness of, moderate hypoglycaemia in healthy volunteers.
During a corticotropin-releasing hormone test in healthy subjects, administration of a beta-adrenergic antagonist induced secretion of cortisol and dehydroepiandrosterone sulfate and inhibited secretion of ACTH.
TLDR
Sympathetic hyperactivity may be a common denominator for low levels of DHEAS in inflammatory and non-inflammatory diseases and a beta-adrenergic influence seems to inhibit adrenal steroids under unstimulated and stimulated conditions.
β-Blockers and Glucose Control
TLDR
In insulin-dependent diabetics, β-blockers can prolong, enhance, or alter the symptoms of hypoglycemia, while hyperglycemia appears to be the major risk in noninsulin-dependentdiabetics.
The possible role of the ancillary properties of beta adrenoceptor antagonists in the management of angina pectoris.
  • J. Fitzgerald
  • Biology, Medicine
    Acta medica Scandinavica. Supplementum
  • 1985
TLDR
It is concluded that selective beta adrenoceptor antagonism confers limited, but tangible advantages over non-selective antagonists in regard to patients with reversible airways obstruction, and also in the metabolic and haemodynamic response to acute hypoglycaemia.
Haemodynamic effects of atenolol, pindolol and propranolol during adrenaline infusion in man
TLDR
It is concluded that a beta1- selective blocker interferes very little with the haemodynamic response to adrenaline, whereas it is changed to a pure pressor response during coadministration of a non-selective betablockers.
β-Adrenoceptor Blocking Agents
TLDR
The first report of s adrenoceptor blocking activity came in 1958 when the properties of dichloroisoprenaline were discovered in animal experiments and while its importance as a pharmacological tool was recognized, the therapeutic potential of this new approach was not.
Lack of β2-adrenoceptor induced long-acting effect on glucose tolerance in type 2 diabetic patients
The effect of metoprolol treatment on insulin sensitivity and diurnal plasma hormone levels in hypertensive subjects
TLDR
The insulin sensitivity index may not accurately reflect the insulin effect as the plasma level of insulin was significantly increased during insulin infusion but not at 24’h, possibly because of alteration of distribution and/or degradation rate of exogenous insulin.
Intrinsic Sympathomimetic Activity: Physiological Reality or Marketing Phenomenon
  • C. Black, H. Mann
  • Medicine, Biology
    Drug intelligence & clinical pharmacy
  • 1984
TLDR
ISA does have a physiological basis and increased experience in larger patient populations will help to place it in proper clinical perspective.
Qualities of an ideal beta-adrenoceptor antagonist and comparison of existing agents with a new cardioselective hydrophilic vasodilator beta-adrenoceptor antagonist, celiprolol.
  • L. Opie
  • Medicine, Biology
    The American journal of cardiology
  • 1988
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