The influence of assay variability on pharmacokinetic parameter estimation

@article{Graves1989TheIO,
  title={The influence of assay variability on pharmacokinetic parameter estimation},
  author={David A. Graves and Charles S. Locke and Keith T. Muir and Richard Paul Miller},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={1989},
  volume={17},
  pages={571-592}
}
The impact of assay variability on pharmacokinetic modeling was investigated. Simulated replications (150) of three “individuals” resulted in 450 data sets. A one-compartment model with first-order absorption was simulated. Random assay errors of 10, 20, or 30% were introduced and the ratio of absorption rate (K a )to elimination rate (K e )constants was 2, 10, or 20. The analyst was blinded as to the rate constants chosen for the simulations. Parameter estimates from the sequential method (K e… CONTINUE READING
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