The influence of ascites on the pharmacokinetics of amikacin.

  title={The influence of ascites on the pharmacokinetics of amikacin.},
  author={Jos{\'e} Mart{\'i}nez Lanao and Alfonso Dom{\'i}nguez-Gil and Jes{\'u}s Garc{\'i}a Mac{\'i}as and Jos{\'e} Luis Gonz{\'a}lez D{\'i}ez and Mar{\'i}a Jes{\'u}s Nieto},
  journal={International journal of clinical pharmacology, therapy, and toxicology},
  volume={18 2},
The pharmacokinetics of Amikacin are studied after the administration of 7.5 mg/kg body weight to 10 ascitic patients diagnosed with various hepatic disorders. The antibiotic was determined microbiologically in plasma and in the ascitic fluid. The antibiotic follows a two-compartment kinetic model, and it may be seen that once the rapid disposition phase has ended, an inflexion in the plasma-time levels curve takes place, with a passing increase in the plasma concentrations. From the… CONTINUE READING

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