The influence of aqueous versus glassy solvents on protein dynamics: vibrational echo experiments and molecular dynamics simulations.

@article{Massari2005TheIO,
  title={The influence of aqueous versus glassy solvents on protein dynamics: vibrational echo experiments and molecular dynamics simulations.},
  author={Aaron M Massari and Ilya J Finkelstein and Brian L McClain and Anne Goj and Xin Wen and Kara L Bren and Roger F Loring and Michael D Fayer},
  journal={Journal of the American Chemical Society},
  year={2005},
  volume={127 41},
  pages={14279-89}
}
Spectrally resolved infrared stimulated vibrational echo measurements are used to measure the vibrational dephasing of the CO stretching mode of carbonmonoxy-hemoglobin (HbCO), a myoglobin mutant (H64V), and a bacterial cytochrome c(552) mutant (Ht-M61A) in aqueous solution and trehalose glasses. The vibrational dephasing of the heme-bound CO is significantly slower for all three proteins embedded in trehalose glasses compared to that of aqueous protein solutions. All three proteins exhibit… CONTINUE READING

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