The influence of a novel pentadecapeptide, BPC 157, on N(G)-nitro-L-arginine methylester and L-arginine effects on stomach mucosa integrity and blood pressure.

@article{Sikiric1997TheIO,
  title={The influence of a novel pentadecapeptide, BPC 157, on N(G)-nitro-L-arginine methylester and L-arginine effects on stomach mucosa integrity and blood pressure.},
  author={Predrag Sikiric and Sven Seiwerth and Z Grabarevi{\'c} and Rudolf Ru{\vc}man and Marijan Petek and Vjekoslav Jagi{\'c} and Branko Turkovi{\'c} and Ivo Rotkvi{\'c} and Stjepan Mi{\vs}e and Ivan Zori{\vc}i{\'c} and Pa{\vs}ko Konjevoda and Daniela Perovi{\'c} and Ljubica Jurina and Jadranka {\vS}eparovi{\'c} and Miro Han{\vz}eva{\vc}ki and Branka Artukovi{\'c} and Mirna Bratuli{\'c} and Marina Ti{\vs}ljar and Miroslav Gjura{\vs}in and Pavao Mikli{\'c} and Dinko Stan{\vc}i{\'c}-Rokotov and Zoran Slobodnjak and Nikola Jelovac and Anton Marovi{\'c}},
  journal={European journal of pharmacology},
  year={1997},
  volume={332 1},
  pages={
          23-33
        }
}
The known effects of a novel stomach pentadecapeptide BPC157 (10 microg or 10 ng/kg), namely its salutary activity against ethanol (96%, i.g.)-induced gastric lesions (simultaneously applied i.p.) and in blood pressure maintenance (given i.v.), were investigated in rats challenged with a combination of N(G)-nitro-L-arginine methylester (L-NAME) (5 mg/kg i.v.), a competitive inhibitor of endothelium nitric oxide (NO)-generation and NO precursor, L-arginine (200 mg/kg i.v.) (D-arginine was… CONTINUE READING

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