The influence of a humectant‐rich mixture on normalz skin barrier function and on once‐ and twice‐daily treatment of foot xerosis. A prospective, randomized, evaluator–blind, bilateral and untreated‐control study

@article{Lden2013TheIO,
  title={The influence of a humectant‐rich mixture on normalz skin barrier function and on once‐ and twice‐daily treatment of foot xerosis. A prospective, randomized, evaluator–blind, bilateral and untreated‐control study},
  author={Marie L{\'o}den and Johan Scheele and Sophie Michelson},
  journal={Skin Research and Technology},
  year={2013},
  volume={19}
}
Moisturizers are often used to overcome dry skin conditions. However, cosmetic moisturizers may lack in efficiency and may also deteriorate skin barrier function. The objective of this study was to generate data on a new humectant‐rich formulation (15% alfahydroxy acids and 15% urea) in the treatment of normal skin as well as in dry feet with hyperkeratosis and cracked skin with fissures. Changes in permeability and effectiveness of the product after once‐ and twice‐daily applications to the… 
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16 Citations
Background Citations
6
Methods Citations
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16 Citations

Citation Type

Citation Type

Effectiveness of Two Moisturizers in the Treatment of Foot Xerosis A Randomized Clinical Trial.
TLDR
In this study, there was no difference between using sorbolene or 25% urea cream to treat symptoms of foot xerosis, and a recommendation cannot be made based on efficacy alone; however, sorbolenes treatments are invariably cheaper than urea-based ones.
The Influence of Two Different Foam Creams on Skin Barrier Repair of Foot Xerosis: A Prospective, Double-Blind, Randomised, Placebo-Controlled Intra-Individual Study
TLDR
This study shows that a quick reorganisation of the SC lipids initiates a good restoration of the whole skin barrier after 4 weeks of treatment with a foam cream.
A Recalcitrant Skin Fissure Treated with an Anionic Polar Phospholipid Emulsion
TLDR
This case demonstrates the superior resolution of a painful skin fissure using an oil-in-water-based skin cream supplemented with APP compared to a skin cream reference common moisturizer.
Emollients in the care of the diabetic foot
TLDR
How dry skin may develop, focussing on the diabetic foot, is reviewed, and an approach to managing this common condition is suggested.
Treatments Improving Skin Barrier Function.
  • M. Lóden
  • Medicine
    Current problems in dermatology
  • 2016
TLDR
Moisturizers affect the stratum corneum architecture and barrier homeostasis, i.e. the production of barrier lipids and the maturation of corneocytes.
Interactions between the stratum corneum and topically applied products: regulatory, instrumental and formulation issues with focus on moisturizers
  • M. Lóden
  • Medicine
    The British journal of dermatology
  • 2014
TLDR
In the present overview, product presentations and mode of actions are reflected against the regulatory demands in Europe, such as the new cosmetic regulation with advice on testing and responsible marketing.
Ultrasound assessment of the keratolitic effect of a 50% urea anhydrous paste on psoriasis plaques: a prospective study.
TLDR
The tested product resulted to be an effective keratolytic agent in plaque psoriasis, allowing to objectively confirm and correlate the epidermal changes seen at clinical evaluation.
Moisturisers for the treatment of foot xerosis: a systematic review
TLDR
A synthesis of available literature suggests that treatments containing urea as a primary active ingredient have been the most researched.
Supportive Skin Care in Older Patients
Overview of the physiologic and morphologic changes in the stratum corneum, the first barrier layer of protection against the environment, that occur with age Effective management of xerosis…
Ethanol-Based Disinfectants Containing Urea May Reduce Soap Sensitivity
  • M. Lóden
  • Medicine
    Dermatitis : contact, atopic, occupational, drug
  • 2020
TLDR
Improved barrier function using this ethanol gel with urea may have relevance in daily disinfectant procedures.
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