The influence of a humectant‐rich mixture on normalz skin barrier function and on once‐ and twice‐daily treatment of foot xerosis. A prospective, randomized, evaluator–blind, bilateral and untreated‐control study
@article{Lden2013TheIO, title={The influence of a humectant‐rich mixture on normalz skin barrier function and on once‐ and twice‐daily treatment of foot xerosis. A prospective, randomized, evaluator–blind, bilateral and untreated‐control study}, author={Marie L{\'o}den and Johan Scheele and Sophie Michelson}, journal={Skin Research and Technology}, year={2013}, volume={19} }
Moisturizers are often used to overcome dry skin conditions. However, cosmetic moisturizers may lack in efficiency and may also deteriorate skin barrier function. The objective of this study was to generate data on a new humectant‐rich formulation (15% alfahydroxy acids and 15% urea) in the treatment of normal skin as well as in dry feet with hyperkeratosis and cracked skin with fissures. Changes in permeability and effectiveness of the product after once‐ and twice‐daily applications to the…
16 Citations
Effectiveness of Two Moisturizers in the Treatment of Foot Xerosis A Randomized Clinical Trial.
- MedicineJournal of the American Podiatric Medical Association
- 2018
In this study, there was no difference between using sorbolene or 25% urea cream to treat symptoms of foot xerosis, and a recommendation cannot be made based on efficacy alone; however, sorbolenes treatments are invariably cheaper than urea-based ones.
The Influence of Two Different Foam Creams on Skin Barrier Repair of Foot Xerosis: A Prospective, Double-Blind, Randomised, Placebo-Controlled Intra-Individual Study
- MedicineSkin Pharmacology and Physiology
- 2016
This study shows that a quick reorganisation of the SC lipids initiates a good restoration of the whole skin barrier after 4 weeks of treatment with a foam cream.
A Recalcitrant Skin Fissure Treated with an Anionic Polar Phospholipid Emulsion
- MedicineFamily Medicine and Primary Care: Open Access
- 2022
This case demonstrates the superior resolution of a painful skin fissure using an oil-in-water-based skin cream supplemented with APP compared to a skin cream reference common moisturizer.
Emollients in the care of the diabetic foot
- Medicine
- 2013
How dry skin may develop, focussing on the diabetic foot, is reviewed, and an approach to managing this common condition is suggested.
Treatments Improving Skin Barrier Function.
- MedicineCurrent problems in dermatology
- 2016
Moisturizers affect the stratum corneum architecture and barrier homeostasis, i.e. the production of barrier lipids and the maturation of corneocytes.
Interactions between the stratum corneum and topically applied products: regulatory, instrumental and formulation issues with focus on moisturizers
- MedicineThe British journal of dermatology
- 2014
In the present overview, product presentations and mode of actions are reflected against the regulatory demands in Europe, such as the new cosmetic regulation with advice on testing and responsible marketing.
Ultrasound assessment of the keratolitic effect of a 50% urea anhydrous paste on psoriasis plaques: a prospective study.
- MedicineGiornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia
- 2019
The tested product resulted to be an effective keratolytic agent in plaque psoriasis, allowing to objectively confirm and correlate the epidermal changes seen at clinical evaluation.
Supportive Skin Care in Older Patients
- Medicine
- 2015
Overview of the physiologic and morphologic changes in the stratum corneum, the first barrier layer of protection against the environment, that occur with age
Effective management of xerosis…
Ethanol-Based Disinfectants Containing Urea May Reduce Soap Sensitivity
- MedicineDermatitis : contact, atopic, occupational, drug
- 2020
Improved barrier function using this ethanol gel with urea may have relevance in daily disinfectant procedures.
Aftershave: a truth behind iconic fragrance
- Medicine
- 2017
Aftershave is an important part of a man's daily lifestyle routine and contains an antiseptic agent such as denatured alcohol, stearate/citrate or witch hazel to prevent infection of cuts, as well as to act as an astringent to reduce skin irritation.
References
SHOWING 1-10 OF 44 REFERENCES
Changes in skin barrier function following long‐term treatment with moisturizers, a randomized controlled trial
- MedicineThe British journal of dermatology
- 2007
This research focuses on the effects on skin barrier function of long‐term treatment with moisturizers in patients with dry skin conditions as well as people with healthy skin.
Objective bioengineering methods to assess the effects of moisturizers on xerotic leg skin of elderly people
- Medicine
- 2000
The glycolic acid lotion weakened the stratum corneum barrier in contrast with Eucerin, which enhanced it, and both treatments were equally effective in smoothing the surface.
Improved topical treatment of lamellar ichthyosis: a double‐blind study of four different cream formulations
- MedicineThe British journal of dermatology
- 1999
Skin hydration and TEWL were both significantly increased by LPL and LPE, whereas skin roughness was reduced most by L PL, and 14 patients preferred LPL over the other cream formulations.
Barrier recovery and influence of irritant stimuli in skin treated with a moisturizing cream
- MedicineContact dermatitis
- 1997
The accelerated rate of recovery of surfactant‐damaged skin and the lower degree of SLS‐induced irritation in normal skin treated with the test cream may be of clinical relevance in attempts to reduce contact dermatitis due to irritant stimuli.
The effect of two moisturisers on skin barrier damage in allergic contact dermatitis.
- MedicineEuropean journal of dermatology : EJD
- 2002
Long-term use of inadequate moisturiser increases skin barrier damage due to Ni-ACD, and TEWL values were significantly increased on the site pre-treated with poorly hydrating product compared to the rich formulation pre- treated site.
Effect of long-term use of moisturizer on skin hydration, barrier function and susceptibility to irritants.
- MedicineActa dermato-venereologica
- 1999
The results suggest that long-term treatment with moisturizers on normal skin may increase skin susceptibility to irritants.
Prevention or promotion of dryness and eczema by moisturizers
- Medicine
- 2008
A defect in skin barrier function has been suggested as the major cause for atopic eczema, and knowledge regarding the mechanisms of the impact of different ingredients on the skin is still lacking.
Urea-containing moisturizers influence barrier properties of normal skin
- Chemistry, MedicineArchives of Dermatological Research
- 2006
Urea was found to decrease the skin susceptibility to SLS after only three applications and the lower degree of SLS-induced irritation in the skin treated previously with urea-containing moisturizers may be of clinical relevance in reducing contact dermatitis from irritant stimuli.
Comparison of salicylic acid and urea versus ammonium lactate for the treatment of foot xerosis. A randomized, double-blind, clinical study.
- MedicineJournal of the American Podiatric Medical Association
- 1998
Irrespective of the mechanism of action, this study shows that both Kerasal and Lac-Hydrin 12% lotion result in reduction in the severity of xerosis after 4 weeks of therapy.
A comparative study of lactic acid 10% and ammonium lactate 12% lotion in the treatment of foot xerosis.
- MedicineJournal of the American Podiatric Medical Association
- 2002
Although both treatment groups had significantly improved xerosis scores after 2 and 4 weeks of treatment, no statistically significant difference was observed.