The influence of UGT2B7 genotype on valproic acid pharmacokinetics in Chinese epilepsy patients

@article{Sun2015TheIO,
  title={The influence of UGT2B7 genotype on valproic acid pharmacokinetics in Chinese epilepsy patients},
  author={Yinxiang Sun and Wen-Yan Zhuo and H. Lin and Z. Peng and F. Tang},
  journal={Epilepsy Research},
  year={2015},
  volume={114},
  pages={78-80}
}
PURPOSE The aim of this study was to investigate the distribution and frequency of genetic polymorphisms in uridine diphosphate glucuronosyltransferase-2B7 (UGT2B7) in epilepsy patients and to evaluate the effect of these on the metabolism of valproic acid (VPA). METHODS Single nucleotide polymorphisms in UGT2B7 were investigated in 102 epilepsy patients using DNA sequencing and polymerase chain reaction-restriction fragment length polymorphism analysis. The steady-state plasma concentrations… Expand
25 Citations
Association of UGT2B7 and UGT1A4 Polymorphisms with Serum Concentration of Antiepileptic Drugs in Children
  • 17
Effect of UGT2B7 genotypes on plasma concentration of valproic acid: a meta-analysis
  • 18
  • Highly Influenced
Genetic polymorphisms and valproic acid plasma concentration in children with epilepsy on valproic acid monotherapy
  • 6
  • Highly Influenced
Population pharmacokinetics of valproic acid in epileptic children: Effects of clinical and genetic factors
  • 6
...
1
2
3
...

References

SHOWING 1-10 OF 14 REFERENCES
Influence of UDP-glucuronosyltransferase polymorphisms on valproic acid pharmacokinetics in Chinese epilepsy patients
  • 55
An association of UDP-glucuronosyltransferase 2B7 C802T (His268Tyr) polymorphism with bladder cancer in benzidine-exposed workers in China.
  • 60
  • PDF
Urinary Excretion of Valproate and Some Metabolites in Chronically Treated Patients
  • 69
Urinary excretion of valproate metabolites in children and adolescents.
  • 12
Clinically relevant drug interactions with antiepileptic drugs.
  • E. Perucca
  • Medicine
  • British journal of clinical pharmacology
  • 2006
  • 455
  • PDF
MECHANISM OF THE DRUG INTERACTION BETWEEN VALPROIC ACID AND CARBAPENEM ANTIBIOTICS IN MONKEYS AND RATS
  • 83
  • PDF
Clinical Pharmacokinetics of Valproic Acid — 1988
  • 166
...
1
2
...