The influence of PKA treatment on the Ca2+ activation of force generation by trout cardiac muscle.

@article{Gillis2011TheIO,
  title={The influence of PKA treatment on the Ca2+ activation of force generation by trout cardiac muscle.},
  author={Todd E Gillis and Jordan M. Klaiman},
  journal={The Journal of experimental biology},
  year={2011},
  volume={214 Pt 12},
  pages={
          1989-96
        }
}
β-Adrenergic stimulation of the mammalian heart increases heart rate, the strength of contraction as well as the kinetics of force generation and relaxation. These effects are due to the phosphorylation of select membrane and thin filament proteins by cAMP-activated protein kinase (PKA). At the level of the sarcomere, it is typically the phosphorylation of cardiac myosin binding protein C (cMyBP-C) and cardiac troponin I (cTnI) that is responsible for the change in the kinetics of contraction… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

Dissecting the role of the myofilament in diaphragm dysfunction during the development of heart failure in mice.

  • American journal of physiology. Heart and circulatory physiology
  • 2016
VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS

Temperature-induced cardiac remodelling in fish

  • The Journal of experimental biology
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND

A functional comparison of cardiac troponin C from representatives of three vertebrate taxa: Linking phylogeny and protein function.

  • Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology
  • 2016
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 39 REFERENCES