The influence of P-glycoprotein expression and its inhibitors on the distribution of doxorubicin in breast tumors

@inproceedings{Patel2009TheIO,
  title={The influence of P-glycoprotein expression and its inhibitors on the distribution of doxorubicin in breast tumors},
  author={Krupa J. Patel and Ian F. Tannock},
  booktitle={BMC Cancer},
  year={2009}
}
Anti-cancer drugs access solid tumors via blood vessels, and must penetrate tumor tissue to reach all cancer cells. Previous studies have demonstrated steep gradients of decreasing doxorubicin fluorescence with increasing distance from blood vessels, such that many tumor cells are not exposed to drug. Studies using multilayered cell cultures show that increased P-glycoprotein (PgP) is associated with better penetration of doxorubicin, while PgP inhibitors decrease drug penetration in tumor… CONTINUE READING

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