The influence of HLA-linked genes on the severity of anti-GBM antibody-mediated nephritis.

@article{Rees1984TheIO,
  title={The influence of HLA-linked genes on the severity of anti-GBM antibody-mediated nephritis.},
  author={Andrew J Rees and Dr T. K. Peters and Nick Amos and Ken Ian Welsh and J. Richard Batchelor},
  journal={Kidney international},
  year={1984},
  volume={26 4},
  pages={445-50}
}
Thirty-nine Caucasian patients with glomerulonephritis caused by autoantibodies to glomerular basement membrane (GBM) were studied. They were segregated into three groups depending on presentation: Group 1 (19 patients) were anuric or oliguric, group 2 (13 patients) had rapidly deteriorating renal function but were not oliguric, and group 3 (seven patients) had stable renal function. The incidence of HLA-DR2 was greatly increased; it was present in 34 of 38 patients in whom DR antigens were… CONTINUE READING

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