The influence of 5-HTTLPR and STin2 polymorphisms in the serotonin transporter gene on treatment effect of selective serotonin reuptake inhibitors in depressive patients.

@article{Smits2008TheIO,
  title={The influence of 5-HTTLPR and STin2 polymorphisms in the serotonin transporter gene on treatment effect of selective serotonin reuptake inhibitors in depressive patients.},
  author={Kim M. Smits and Luc Jm Smits and Frenk Peeters and Jan S. A. G. Schouten and Rob G J H Janssen and Hubert J. M. Smeets and Jim van Os and Martin H. Prins},
  journal={Psychiatric genetics},
  year={2008},
  volume={18 4},
  pages={184-90}
}
BACKGROUND Serotonin transporter gene (SLC6A4) variations have been proposed as an explanation for interindividual differences in selective serotonin reuptake inhibitors (SSRIs) effects. Quantitative assessment of genetic influences is necessary to evaluate whether genetic testing before antidepressant prescription would lead to earlier treatment effects. This study evaluates the influence of two polymorphisms (5-HTTLPR and STin2) on SSRI treatment outcome in depression. METHODS We included… CONTINUE READING

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