The inflammatory network in the gastrointestinal tumor microenvironment: lessons from mouse models

@article{Oshima2011TheIN,
  title={The inflammatory network in the gastrointestinal tumor microenvironment: lessons from mouse models},
  author={Hiroko Oshima and Masanobu Oshima},
  journal={Journal of Gastroenterology},
  year={2011},
  volume={47},
  pages={97-106}
}
Accumulating evidence has indicated that inflammatory responses are important for cancer development. Epidemiological studies have shown that regular use of non-steroidal anti-inflammatory drugs (NSAIDs) reduces the risk of colon cancer development. Subsequently, mouse genetic studies have shown that cyclooxygenase (COX)-2, one of the target molecules of NSAIDs, and its downstream product, prostaglandin E2 (PGE2), play an important role in gastrointestinal tumorigenesis. Bacterial infection… CONTINUE READING