• DOI:10.1681/ASN.2010101073
Corpus ID: 32604679

The inflammatory cytokines TWEAK and TNFα reduce renal klotho expression through NFκB.

@article{Moreno2011TheIC,
  title={The inflammatory cytokines TWEAK and TNF$\alpha$ reduce renal klotho expression through NF$\kappa$B.},
  author={J. Moreno and M. C. Izquierdo and M. S{\'a}nchez-Ni{\~n}o and B. Suarez-Alvarez and C. Lopez-Larrea and A. Jakubowski and J. Blanco and R. Ram{\'i}rez and R. Selgas and M. Ruiz-Ortega and J. Egido and A. Ortiz and A. Sanz},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2011},
  volume={22 7},
  pages={
          1315-25
        }
}

• J. Moreno, M. C. Izquierdo, +10 authors A. Sanz
• Published 2011
• Biology, Medicine
• Journal of the American Society of Nephrology : JASN

Proinflammatory cytokines contribute to renal injury, but the downstream effectors within kidney cells are not well understood. One candidate effector is Klotho, a protein expressed by renal cells that has antiaging properties; Klotho-deficient mice have an accelerated aging-like phenotype, including vascular injury and renal injury. Whether proinflammatory cytokines, such as TNF and TNF-like weak inducer of apoptosis (TWEAK), modulate Klotho is unknown. In mice, exogenous administration of… Expand