The inflammatory cytokines TWEAK and TNFα reduce renal klotho expression through NFκB.

@article{Moreno2011TheIC,
  title={The inflammatory cytokines TWEAK and TNF$\alpha$ reduce renal klotho expression through NF$\kappa$B.},
  author={Juan Antonio Moreno and Mar{\'i}a Concepci{\'o}n Izquierdo and Maria Dolores S{\'a}nchez-Ni{\~n}o and Beatriz Suarez-Alvarez and Carlos L{\'o}pez-Larrea and Aniela Jakubowski and Juli{\`a} Blanco and Rafael Ram{\'i}rez and Rafael Selgas and Marta Ru{\'i}z-Ortega and Jesus Egido and Alberto Ortiz and Ana Bel{\'e}n Sanz},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2011},
  volume={22 7},
  pages={
          1315-25
        }
}
Proinflammatory cytokines contribute to renal injury, but the downstream effectors within kidney cells are not well understood. One candidate effector is Klotho, a protein expressed by renal cells that has antiaging properties; Klotho-deficient mice have an accelerated aging-like phenotype, including vascular injury and renal injury. Whether proinflammatory cytokines, such as TNF and TNF-like weak inducer of apoptosis (TWEAK), modulate Klotho is unknown. In mice, exogenous administration of… 

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TWEAK and the progression of renal disease: clinical translation.
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    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2014
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PGC1α Plays a Critical Role in TWEAK–Induced Cardiac Dysfunction
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