The inflammatory cytokine TNF-α promotes the premature senescence of rat nucleus pulposus cells via the PI3K/Akt signaling pathway

@article{Li2017TheIC,
  title={The inflammatory cytokine TNF-α promotes the premature senescence of rat nucleus pulposus cells via the PI3K/Akt signaling pathway},
  author={P. Li and Y. Gan and Y. Xu and L. Song and L. Wang and B. Ouyang and C. Zhang and Qiang Zhou},
  journal={Scientific Reports},
  year={2017},
  volume={7}
}
  • P. Li, Y. Gan, +5 authors Qiang Zhou
  • Published 2017
  • Chemistry, Medicine
  • Scientific Reports
Premature senescence of nucleus pulposus (NP) cells and inflammation are two common features of degenerated discs. This study investigated the effects of the inflammatory cytokine TNF-α on the premature senescence of NP cells and the molecular mechanism behind this process. Rat NP cells were cultured with or without different concentrations of TNF-α for 1 and 3 days. The inhibitor LY294002 was used to determine the role of the PI3K/Akt pathway. NP cells that were incubated with TNF-α for 3 days… Expand
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