The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice.

@article{Wu2006TheIN,
  title={The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice.},
  author={D Christine Wu and Diane B{\'e}rang{\`e}re R{\'e} and Makiko Nagai and Harry Ischiropoulos and Serge E. Przedborski},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 32},
  pages={12132-7}
}
ALS is a fatal paralytic disorder characterized by a progressive loss of spinal cord motor neurons. Herein, we show that NADPH oxidase, the main reactive oxygen species-producing enzyme during inflammation, is activated in spinal cords of ALS patients and in spinal cords in a genetic animal model of this disease. We demonstrate that inactivation of NADPH oxidase in ALS mice delays neurodegeneration and extends survival. We also show that NADPH oxidase-derived oxidant products damage proteins… CONTINUE READING
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