The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

@article{Maes2008TheI,
  title={The inflammatory \& neurodegenerative (I\&ND) hypothesis of depression: leads for future research and new drug developments in depression},
  author={Michael Maes and Raz Yirmyia and J. Noraberg and S. Brené and J. Hibbeln and G. Perini and M. Kubera and P. Bob and B. Lerer and M. Maj},
  journal={Metabolic Brain Disease},
  year={2008},
  volume={24},
  pages={27-53}
}
Despite extensive research, the current theories on serotonergic dysfunctions and cortisol hypersecretion do not provide sufficient explanations for the nature of depression. Rational treatments aimed at causal factors of depression are not available yet. With the currently available antidepressant drugs, which mainly target serotonin, less than two thirds of depressed patients achieve remission. There is now evidence that inflammatory and neurodegenerative (I&ND) processes play an important… Expand

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