The inflammation hypothesis and its potential relevance to statin therapy.

  title={The inflammation hypothesis and its potential relevance to statin therapy.},
  author={James S. Forrester and P. Scott Libby},
  journal={The American journal of cardiology},
  volume={99 5},
Inflammatory cytokines have a central role in atherogenesis and plaque rupture. These mediators, including tumor necrosis factor, interleukins, and matrix metalloproteinases and transforming growth factor-beta are also prominent in other chronic progressive diseases characterized by cell apoptosis and tissue fibrosis. This review extends the inflammation hypothesis to critical analysis of studies to bearing on the role of inflammation in chronic conditions that commonly accompany coronary… CONTINUE READING

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