The inflammasome adaptor ASC regulates adaptive immune cell functions by controlling DOCK2-mediated Rac activation and actin polymerization

@inproceedings{Ippagunta2011TheIA,
  title={The inflammasome adaptor ASC regulates adaptive immune cell functions by controlling DOCK2-mediated Rac activation and actin polymerization},
  author={Sirish K Ippagunta and R K Subbarao Malireddi and Patrick J. Shaw and Geoffrey Neale and Lieselotte Vande Walle and Douglas R Green and Yoshinori Fukui and Mohamed Lamkanfi and Thirumala-Devi Kanneganti},
  booktitle={Nature Immunology},
  year={2011}
}
The adaptor ASC contributes to innate immunity through the assembly of inflammasome complexes that activate the cysteine protease caspase-1. Here we demonstrate that ASC has an inflammasome-independent, cell-intrinsic role in cells of the adaptive immune response. ASC-deficient mice showed defective antigen presentation by dendritic cells (DCs) and lymphocyte migration due to impaired actin polymerization mediated by the small GTPase Rac. Genome-wide analysis showed that ASC, but not the… CONTINUE READING
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The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock 2 - mediated Rac activation and actin polymerization

  • S. K. Ippagunta
  • Nat . Immunol .
  • 2011

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