The inflammasome: Learning from bacterial evasion strategies.

@article{Shin2015TheIL,
  title={The inflammasome: Learning from bacterial evasion strategies.},
  author={Sunny Shin and Igor E Brodsky},
  journal={Seminars in immunology},
  year={2015},
  volume={27 2},
  pages={102-10}
}
The innate immune system plays a critical role in defense against microbial infection and employs germline-encoded pattern recognition receptors to detect broadly conserved microbial structures or activities. Pattern recognition receptors of the nucleotide binding domain/leucine rich repeat (NLR) family respond to particular microbial products or disruption of cellular physiology, and mediate the activation of an arm of the innate immune response termed the inflammasome. Inflammasomes are… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Activation and Evasion of Inflammasomes by Yersinia.

Current topics in microbiology and immunology • 2016
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 135 references

Caspase - 1 autoproteol - ysis is differentially required for NLRP 1 b and NLRP 3 inflammasome function

M. Bodnar Guey, S. N. Manie, A. Tardivel, V. Petrilli
Proc . Natl . Acad . Sci . U . S . A . • 2014

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.

Proceedings of the National Academy of Sciences of the United States of America • 2014

Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS.

Proceedings of the National Academy of Sciences of the United States of America • 2014

Similar Papers

Loading similar papers…