The infection of microvascular endothelial cells with ExoU-producing Pseudomonas aeruginosa triggers the release of von Willebrand factor and platelet adhesion.

@article{Freitas2012TheIO,
  title={The infection of microvascular endothelial cells with ExoU-producing Pseudomonas aeruginosa triggers the release of von Willebrand factor and platelet adhesion.},
  author={Carla Maria Boquimpani de Moura Freitas and M L B Assis and Alessandra Mattos Saliba and Veronica Maria Morandi and Camila Castro Figueiredo and M{\'i}rian S. C. Pereira and Maria-Cristina Maciel Plotkowski},
  journal={Memorias do Instituto Oswaldo Cruz},
  year={2012},
  volume={107 6},
  pages={728-34}
}
An increased plasma concentration of von Willebrand factor (vWF) is detected in individuals with many infectious diseases and is accepted as a marker of endothelium activation and prothrombotic condition. To determine whether ExoU, a Pseudomonas aeruginosa cytotoxin with proinflammatory activity, enhances the release of vWF, microvascular endothelial cells… CONTINUE READING