The induction of virus-specific CTL as a function of increasing epitope expression: responses rise steadily until excessively high levels of epitope are attained.

@article{Wherry1999TheIO,
  title={The induction of virus-specific CTL as a function of increasing epitope expression: responses rise steadily until excessively high levels of epitope are attained.},
  author={Elaine Wherry and Kristin A. Puorro and Angel Porgador and Laurence Eisenlohr},
  journal={Journal of immunology},
  year={1999},
  volume={163 7},
  pages={3735-45}
}
The role of epitope expression levels in CD8+ T cell priming has been controversial. Yet this parameter is of great importance in the design of rational approaches to optimize CTL responses to a variety of pathogens. In this paper we examine the influence of epitope production on CD8+ T cell priming by exploiting a system that allows a 200-fold range of cell surface epitope expression in vitro with a fixed dose of vaccinia virus. Our results demonstrate that, with the exception of a notable… CONTINUE READING

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