The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells

@inproceedings{Ringer2014TheIO,
  title={The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells},
  author={Lymor Ringer and Paul Sirajuddin and Lucas Tricoli and Sarah E. Waye and Muhammad Umer Choudhry and Erika Parasido and Angiela Sivakumar and Mary Mazzotta Heckler and Aisha Naeem and Iman Abdelgawad and Xuefeng Liu and Adam S. Feldman and Richard W. W. Lee and C. F. Jeff Wu and Venkata Mahidhar Yenugonda and Bhaskar V. S. Kallakury and Anatoly Dritschilo and John H. Lynch and Richard J. Schlegel and Olga C. Rodriguez and Richard Q.W. Pestell and Maria Avantaggiati and Chris Albanese},
  booktitle={Oncotarget},
  year={2014}
}
The p53 tumor suppressor protein plays a crucial role in influencing cell fate decisions in response to cellular stress. As p53 elicits cell cycle arrest, senescence or apoptosis, the integrity of the p53 pathway is considered a key determinant of anti-tumor responses. p53 can also promote autophagy, however the role of p53-dependent autophagy in chemosensitivity is poorly understood. VMY-1-103 (VMY), a dansylated analog of purvalanol B, displays rapid and potent anti-tumor activities, however… CONTINUE READING

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