The induction of lipid peroxidation by E. coli lipopolysaccharide on rat hepatocytes as an important factor in the etiology of endotoxic liver damage.

@article{Portols1993TheIO,
  title={The induction of lipid peroxidation by E. coli lipopolysaccharide on rat hepatocytes as an important factor in the etiology of endotoxic liver damage.},
  author={Mar{\'i}a Teresa Portol{\'e}s and M. Jes{\'u}s Ainaga and Raffaella Pagani},
  journal={Biochimica et biophysica acta},
  year={1993},
  volume={1158 3},
  pages={287-92}
}
Oxygen-derived radicals have been suggested to produce tissue injury during endotoxic shock by initiating lipid peroxidation. In order to investigate the induction of lipid peroxidation by Escherichia coli 0111:B4 lipopolysaccharide (LPS) on hepatocytes, malondialdehyde (MDA) and superoxide dismutase (SOD) activity have been evaluated in vivo and in vitro using two experimental models: rat liver after the establishment of endotoxic reversible shock, and cultured hepatocytes after treatment with… CONTINUE READING

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