The induction of intestinal neoplasms in rats with the glycoside cycasin and its aglycone

Experiments are described dealing with the carcinogenic effects of (1) the crude cycad seed material, (2) the glycoside, cycasin, aβ-D-glucosyloxyazoxymethane, isolated from the crude material, and (3) the first metabolic breakdown product of cycasin, the aglycone of cycasin or methylazoxymethanol, on the intestinal tract of rats. While the crude material… CONTINUE READING