The induction of in vivo proliferation of long-lived CD44hi CD8+ T cells after the injection of tumor cells expressing IFN-alpha1 into syngeneic mice.

@article{Belardelli1998TheIO,
  title={The induction of in vivo proliferation of long-lived CD44hi CD8+ T cells after the injection of tumor cells expressing IFN-alpha1 into syngeneic mice.},
  author={Filippo Belardelli and Maria Ferrantini and Stefano Maria Santini and Sara Baccarini and Enrico Proietti and Mario P Colombo and Jon Sprent and David F. Tough},
  journal={Cancer research},
  year={1998},
  volume={58 24},
  pages={5795-802}
}
The tumorigenicity of transplantable tumor cells in mice is reduced by transduction with cytokine genes, including IFN-alpha and interleukin (IL) 12. Although T cells are considered important in tumor rejection, the mechanism by which genetically modified tumor cells stimulate the immune system has not been examined. In this study, the in vivo proliferation of T-cell subsets in mice transplanted with cytokine-producing syngeneic tumor cells was assessed by administering the DNA precursor… CONTINUE READING

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