The induction of cytotoxic T-cell responses with H-2 antigens shed from viable lymphocytes.

Supernatant derived from the incubation of normal, unstimulated spleen cells was able to stimulate a strong specific in vitro cytotoxic lymphocyte (CTL) response in allogeneic spleen cells primed with the corresponding haplotype. The supernatant antigen (SA) was as efficient in inducing secondary CTLs as equivalent numbers of irradiated, adherent cell… CONTINUE READING