The induction of cyclooxygenase-2 in IL-1beta-treated endothelial cells is inhibited by prostaglandin E2 through cAMP.

@article{Akarasereenont1999TheIO,
  title={The induction of cyclooxygenase-2 in IL-1beta-treated endothelial cells is inhibited by prostaglandin E2 through cAMP.},
  author={Pravit Akarasereenont and Kitirat Techatrisak and Sirikul Chotewuttakorn and Athiwat Thaworn},
  journal={Mediators of Inflammation},
  year={1999},
  volume={8},
  pages={287 - 294}
}
Prostaglandins (PGs) have numerous cardiovascular and inflammatory effects. Cyclooxygenase (COX), which exists as COX-1 and COX-2 isoforms, is the first enzyme in the pathway in which arachidonic acid is converted to PGs. Prostaglandin E2 (PGE2) exerts a variety of biological activities for the maintenance of local homeostasis in the body. Elucidation of PGE2 involvement in the signalling molecules such as COX could lead to potential therapeutic interventions. Here, we have investigated the… CONTINUE READING
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