The induction of congenital spinal deformities in mice by maternal carbon monoxide exposure.

@article{Loder2000TheIO,
  title={The induction of congenital spinal deformities in mice by maternal carbon monoxide exposure.},
  author={Randall T Loder and Milton Hernandez and Amy L. Lerner and D J Winebrener and Steven A. N. Goldstein and Robert N. Hensinger and Chui Yu Liu and M. Anthony Schork},
  journal={Journal of pediatric orthopedics},
  year={2000},
  volume={20 5},
  pages={662-6}
}
Carbon monoxide (CO) has been shown to be teratogenic in mice. High altitude hypoxia has also been shown to induce congenital vertebral anomalies in mice. The purpose of this study was to investigate the effect of maternal hypoxia owing to CO exposure and the production of congenital spinal deformities in the offspring. Sixty DBA-1J mice were bred using polygamous timed breeding methods. Pregnant females were exposed to 200, 400, or 600 ppm CO using a custom-designed gas blender system. Seven… CONTINUE READING

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