The induction of cell cycle regulatory and DNA repair proteins in cisplatin-induced acute renal failure.

@article{Zhou2004TheIO,
  title={The induction of cell cycle regulatory and DNA repair proteins in cisplatin-induced acute renal failure.},
  author={Hua Zhou and Akihiko Kawaguchil yoshihiro Kato and Hideo Yasuda and Takehiko Miyaji and Yoshihida Fujigaki and Tatsuo Yamamoto and Katushiko Yonemura and Akira Hishida},
  journal={Toxicology and applied pharmacology},
  year={2004},
  volume={200 2},
  pages={111-20}
}
The purpose of this study was to evaluate the expressions and the roles of proteins involved in cell cycle regulation and DNA repair in cis-diamminedichloroplatinum (II) (cisplatin or CDDP)-induced acute renal failure (ARF). Treatment with CDDP (6 mg/kg, iv) induced tubular damage and increased serum creatinine (Scr) and the number of TUNEL-positive cells in the outer stripe of the outer medulla in rats, which reached peak levels at 5 days after CDDP. The expressions of cyclin-dependent kinase… CONTINUE READING
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