The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose

@article{Defenouillre2019TheIO,
  title={The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose},
  author={Quentin Defenouill{\`e}re and Agathe Verraes and Clotilde Laussel and A. Friedrich and Joseph Schacherer and S. L{\'e}on},
  journal={Science Signaling},
  year={2019},
  volume={12}
}
An evolutionarily conserved family of phosphatases enables cells to resist the toxic metabolic effects of 2-deoxyglucose. Resisting a metabolic poison Once imported into cells and phosphorylated, the glucose analog 2-deoxyglucose (2DG) inhibits glycolysis, leading to the proposal of using 2DG as a cancer treatment. Using yeast as a model, Defenouillère et al. investigated how cells become resistant to 2DG. Exposure to 2DG activated several signaling pathways that resulted in the increased… Expand
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