The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose

Quentin Defenouillère; Agathe Verraes; Clotilde Laussel; A. Friedrich; Joseph Schacherer; S. Léon

DOI:10.1126/scisignal.aaw8000

Corpus ID: 201829818

The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose

@article{Defenouillre2019TheIO,
  title={The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose},
  author={Quentin Defenouill{\`e}re and Agathe Verraes and Clotilde Laussel and A. Friedrich and Joseph Schacherer and S. L{\'e}on},
  journal={Science Signaling},
  year={2019},
  volume={12}
}

Quentin Defenouillère, Agathe Verraes, +3 authors S. Léon
Published 2019
Chemistry, Medicine
Science Signaling

An evolutionarily conserved family of phosphatases enables cells to resist the toxic metabolic effects of 2-deoxyglucose. Resisting a metabolic poison Once imported into cells and phosphorylated, the glucose analog 2-deoxyglucose (2DG) inhibits glycolysis, leading to the proposal of using 2DG as a cancer treatment. Using yeast as a model, Defenouillère et al. investigated how cells become resistant to 2DG. Exposure to 2DG activated several signaling pathways that resulted in the increased… Expand

View on Science

8 Citations

Background Citations

Topics from this paper

Cellular toxicity of the metabolic inhibitor 2-deoxyglucose and associated resistance mechanisms.

Clotilde Laussel, S. Léon
Medicine, Chemistry
Biochemical pharmacology
2020

Spontaneous mutations that confer resistance to 2-deoxyglucose act through Hxk2 and Snf1 pathways to regulate gene expression and HXT endocytosis

Samantha R Soncini, Dakshayini G. Chandrashekarappa, D. A. Augustine, K. Callahan, A. F. O'Donnell, M. C. Schmidt
Biology, Medicine
PLoS genetics
2020

Spontaneous mutations that confer resistance to 2-deoxyglucose act through Hxk2 and Snf1 pathways to regulate gene expression and HXT endocytosis

Samantha R Soncini, Dakshayini G. Chandrashekarappa, D. A. Augustine, K. Callahan, A. F. O'Donnell, M. C. Schmidt
Biology
2019

‘Sugarcoating’ 2-deoxyglucose: mechanisms that suppress its toxic effects

M. C. Schmidt, A. F. O'Donnell
Biology, Medicine
Current genetics
2020

Glycolysis inhibition and apoptosis induction in human prostate cancer cells by FV-429-mediated regulation of AR-AKT-HK2 signaling network.

X. Chen, Libin Wei, Liliang Yang, Wenjing Guo, Qinglong Guo, Yuxin Zhou
Chemistry, Medicine
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
2020