The induction and suppression of c-fos expression in the rat brain by cholecystokinin and its antagonist L364,718.

@article{Chen1993TheIA,
  title={The induction and suppression of c-fos expression in the rat brain by cholecystokinin and its antagonist L364,718.},
  author={Dr. Yijiang Chen and J. A. Deutsch and M Fernanda Gonz{\'a}lez and Yiran Gu},
  journal={Neuroscience letters},
  year={1993},
  volume={149 1},
  pages={91-4}
}
Immunohistochemical techniques were used to map c-fos expression in the rat brain after the i.p. administration of CCK-8 (8 micrograms/kg). C-fos expression was observed in the rostral and the caudal parts of the nuclei of the solitary tract (NTS), and the paraventricular nuclei (PVN) in the hypothalamus. The c-fos expression in these areas was suppressed by the administration of L364,718 (120 micrograms/kg). Since L364,718 is known to be a powerful selective antagonist to the peripheral CCK-A… CONTINUE READING
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