The induction and competitive inhibition of a high affinity microsomal nitrosodimethylamine demethylase by ethanol.

@article{Peng1982TheIA,
  title={The induction and competitive inhibition of a high affinity microsomal nitrosodimethylamine demethylase by ethanol.},
  author={Renxiu Peng and Yahong Tu and Chung S Yang},
  journal={Carcinogenesis},
  year={1982},
  volume={3 12},
  pages={1457-61}
}
The effects of ethanol on the metabolism of nitrosamines by rat liver microsomes have been studied. Treatment of rats with 10 or 15% ethanol in drinking water for 3 days causes a 4- to 5-fold enhancement in microsomal N-nitrosodimethylamine demethylase (NDMAd) activity and a 40-60% increase in gross P-450 content. The enhancement is mainly due to the induction of a low Km form (Km = 0.07 mM) of NDMAd. The treatment induces protein species with molecular weights between 50000 and 52000, some of… CONTINUE READING