The inducible isoform of CREM (inducible cAMP early repressor, ICER) is a repressor of CYP19 rat ovarian promoter.

@article{Morales2003TheII,
  title={The inducible isoform of CREM (inducible cAMP early repressor, ICER) is a repressor of CYP19 rat ovarian promoter.},
  author={Victoria Morales and Ignacio J Gonzalez-Robayna and Inmaculada Hern{\'a}ndez and J. {\'A}lvarez Quintana and Pino Santana and Carlos M Ruiz de Galarreta and Luisa F. Fanjul},
  journal={The Journal of endocrinology},
  year={2003},
  volume={179 3},
  pages={417-25}
}
The synthesis of estradiol by the granulosa cells is a prominent event in ovarian physiology and depends on the expression of P450(AROM). FSH induces the expression of P450(AROM) in granulosa cells as a result of the presence in the ovarian promoter of a CRE (cAMP response element)-like sequence (CLS). In rodents, LH downregulates aromatase expression during luteinization by an as yet undescribed mechanism. In granulosa cells, LH increases the expression of the inducible cAMP early repressor… CONTINUE READING