The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy.

@article{Zhdanova2011TheID,
  title={The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy.},
  author={O. A. Zhdanova and Shekhar Srivastava and Lie Di and Zhai Li and Leila Tchelebi and Sara Dworkin and Duncan B. Johnstone and Jiri Zavadil and Mark M. W. Chong and Dan R. Littman and Lawrence B. Holzman and Laura M C Barisoni and Edward Y Skolnik},
  journal={Kidney international},
  year={2011},
  volume={80 7},
  pages={719-30}
}
Micro-RNAs (miRNAs) are short (average 22 nucleotides) noncoding regulatory RNAs that inhibit gene expression by targeting complementary 3'-untranslated regions of protein-encoding mRNAs for translational repression or degradation. miRNAs play key roles in both the function and differentiation of many cell types. Drosha and Dicer, two RNAase III enzymes, function in a stepwise manner to generate a mature miRNA. Previous studies have shown that podocyte-specific deletion of Dicer during… CONTINUE READING
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