The inducible and cytochrome P450-containing dehydroepiandrosterone 7α-hydroxylating enzyme system of Fusarium moniliforme
@article{Cotillon1997TheIA, title={The inducible and cytochrome P450-containing dehydroepiandrosterone 7$\alpha$-hydroxylating enzyme system of Fusarium moniliforme }, author={A. C. Cotillon and Jaleh Doostzadeh and Robert Morfin}, journal={The Journal of Steroid Biochemistry and Molecular Biology}, year={1997}, volume={62}, pages={467-475} }
22 Citations
Hydroxylation of DHEA and its analogues by Absidia coerulea AM93. Can an inducible microbial hydroxylase catalyze 7α- and 7β-hydroxylation of 5-ene and 5α-dihydro C19-steroids?
- Chemistry, BiologyBioorganic & medicinal chemistry
- 2014
Transformation of 3-hydroxy-steroids by Fusarium moniliforme 7α-hydroxylase
- Chemistry, BiologyThe Journal of Steroid Biochemistry and Molecular Biology
- 1999
Hydroxylation of DHEA, androstenediol and epiandrosterone by Mortierella isabellina AM212. Evidence indicating that both constitutive and inducible hydroxylases catalyze 7α- as well as 7β-hydroxylations of 5-ene substrates.
- Biology, ChemistryOrganic & biomolecular chemistry
- 2011
Ketoconazole and cycloheximide inhibition studies suggest the presence of constitutive and substrate-induced hydroxylases in M. isabellina on the basis of time course analysis of theHydroxylation of DHEA and androstenediol.
The human cytochrome P4507B1: catalytic activity studies
- Biology, ChemistryThe Journal of Steroid Biochemistry and Molecular Biology
- 2004
Biotransformation of Cholesterol and 16α,17α-Epoxypregnenolone and Isolation of Hydroxylase in Burkholderia cepacia SE-1
- BiologyBioMed research international
- 2016
The biotransformation products of cholesterol and 16α,17α-epoxypregnenolone produced by Burkholderia cepacia SE-1 were investigated and a correlative enzyme, hydroxylase, was studied.
Novel metabolites of dehydroepiandrosterone and progesterone obtained in Didymosphearia igniaria KCH 6670 culture
- Chemistry, Biology
- 2012
Screening of mycelial fungi for 7α- and 7β-hydroxylase activity towards dehydroepiandrosterone
- Biology
- 2007
In total, 481 fungal strains were screened for the ability to carry out 7(α/β)-hydroxylation of dehydroepiandrosterone (DHEA, 3β-hydroxy-5-androsten-17-one), and the majority of strains were able to introduce a hydroxyl group to position 7α.
Dehydroepiandrosterone Metabolites and their Interactions in Humans
- Biology, ChemistryDrug metabolism and drug interactions
- 2006
The cytochrome P4507B1 responsible for 7alpha-hydroxy-DHEA production and 11beta-HSD1 are key enzymes for the modulation of glucocorticoid action in humans.
Transformations of 4- and 17α-substituted testosterone analogues by Fusarium culmorum
- Biology, ChemistrySteroids
- 2005
Dihydroxylation of dehydroepiandrosterone in positions 7α and 15α by mycelial fungi
- Biology, ChemistryApplied Biochemistry and Microbiology
- 2009
Application of the revealed active strains of microorganisms opens prospects for the efficient production of key intermediates of synthesis of modern medical preparations.
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