The independent cue and cus systems confer copper tolerance during aerobic and anaerobic growth in Escherichia coli.

@article{Outten2001TheIC,
  title={The independent cue and cus systems confer copper tolerance during aerobic and anaerobic growth in Escherichia coli.},
  author={F Wayne Outten and Danielle L. Huffman and John D. F. Hale and Thomas V O'Halloran},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 33},
  pages={
          30670-7
        }
}

• F Wayne Outten, Danielle L. Huffman, +1 author Thomas V O'Halloran
• Published 2001 in The Journal of biological chemistry

Copper is essential but can be toxic even at low concentrations. Coping with this duality requires multiple pathways to control intracellular copper availability. Three copper-inducible promoters, controlling expression of six copper tolerance genes, were recently identified in Escherichia coli. The cue system employs an inner membrane copper transporter, whereas the cus system includes a tripartite transporter spanning the entire cell envelope. Although cus is not essential for aerobic copper… CONTINUE READING

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