The independent cue and cus systems confer copper tolerance during aerobic and anaerobic growth in Escherichia coli.

@article{Outten2001TheIC,
  title={The independent cue and cus systems confer copper tolerance during aerobic and anaerobic growth in Escherichia coli.},
  author={F Wayne Outten and Danielle L. Huffman and John D. F. Hale and Thomas V O'Halloran},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 33},
  pages={
          30670-7
        }
}
Copper is essential but can be toxic even at low concentrations. Coping with this duality requires multiple pathways to control intracellular copper availability. Three copper-inducible promoters, controlling expression of six copper tolerance genes, were recently identified in Escherichia coli. The cue system employs an inner membrane copper transporter, whereas the cus system includes a tripartite transporter spanning the entire cell envelope. Although cus is not essential for aerobic copper… CONTINUE READING
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