The increasing complexity of mercaptopurine pharmacogenomics.

  title={The increasing complexity of mercaptopurine pharmacogenomics.},
  author={Sharon Marsh and Derek J. Van Booven},
  journal={Clinical pharmacology and therapeutics},
  volume={85 2},
Thiopurine methyltransferase (TPMT) activity shows significant interindividual variation, with approximately 90% of individuals having high (wild-type) activity, 10% with intermediate activity, and 0.3% with low activity. Low and intermediate TPMT activity leads to toxicity from mercaptopurine and the need for dose reduction. Common variants in the TPMT gene have a strong association with mercaptopurine toxicity. However, recent research has shown that genetic contribution to mercaptopurine… CONTINUE READING

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