The increased swelling and instantaneous deformation of osteoarthritic cartilage is highly correlated with collagen degradation.

@article{Bank2000TheIS,
  title={The increased swelling and instantaneous deformation of osteoarthritic cartilage is highly correlated with collagen degradation.},
  author={Ruud A. Bank and Michael Soudry and Alice Maroudas and Joe Mizrahi and J M Tekoppele},
  journal={Arthritis and rheumatism},
  year={2000},
  volume={43 10},
  pages={
          2202-10
        }
}
OBJECTIVE To provide evidence for the hypothesis that the loss of tensile strength of osteoarthritic (OA) cartilage (resulting in swelling-the hallmark of OA) is due to an impaired collagen network and not to loss or degradation of proteoglycans. METHODS The amount of degraded collagen molecules, the fixed charge density (FCD) on a dry-weight basis, the degree of swelling in saline, and the instantaneous deformation (ID; a test reflecting the tensile stiffness of the collagen network) were… CONTINUE READING
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