The increase in serum soluble ST2 protein upon acute exacerbation of idiopathic pulmonary fibrosis.

@article{Tajima2003TheII,
  title={The increase in serum soluble ST2 protein upon acute exacerbation of idiopathic pulmonary fibrosis.},
  author={Shunji Tajima and Katsuhisa Oshikawa and Shin-ichi Tominaga and Yukihiko Sugiyama},
  journal={Chest},
  year={2003},
  volume={124 4},
  pages={1206-14}
}
BACKGROUND The human ST2 gene can be specifically induced by growth stimulation in fibroblastic cells, and the soluble ST2 protein (ST2) is expressed preferentially in T-helper type 2 (Th2) cells. Furthermore, ST2 is induced by proinflammatory stimuli such as tumor necrosis factor-alpha and interleukin-1 beta. It has been reported that the inflammatory response in idiopathic pulmonary fibrosis (IPF) is thought to be associated with proinflammatory cytokines and Th2 immune response. STUDY… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 63 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Expression and function of the ST2 gene in a murine model of allergic airway inflammation.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology • 2002

IL-12 attenuates bleomycin-induced pulmonary fibrosis.

American journal of physiology. Lung cellular and molecular physiology • 2001

Idiopathic pulmonary fibrosis.

The New England journal of medicine • 2001

Similar Papers

Loading similar papers…