The increase in glucose-6-phosphate content of the heart after the administration of inotropic catecholamines, calcium, and aminophylline.

@article{Belford1962TheII,
  title={The increase in glucose-6-phosphate content of the heart after the administration of inotropic catecholamines, calcium, and aminophylline.},
  author={J Belford and Marcia R. Feinleib},
  journal={Biochemical pharmacology},
  year={1962},
  volume={11},
  pages={
          987-94
        }
}

THE EFFECTS OF ADRENALINE AND OTHER DRUGS AFFECTING CARBOHYDRATE METABOLISM ON CONTRACTIONS OF THE RAT DIAPHRAGM.

The ability of several drugs to restore directly elicited twitches of the rat diaphragm depressed by excess potassium chloride has been studied and the suggestion by Ellis (1955) that the effect on contractions may be a result of increased intracellular hexosephosphate levels is discussed.

The action of adrenaline in cardiac muscle. Dissociation between phosphorylase activation and inotropic response.

The results imply that phosphorylase activation and inotropic response might be triggered by the same initial event, in spite of the dissociation, which has been observed between these two adrenergic effects.

Hemodynamic effects of aminophylline in heart failure.

Über die unterschiedliche Wirkung von Calcium und Noradrenalin auf den Sauerstoffverbrauch isolierter Meerschweinchenvorhöfe

SummaryThe influence of various concentrations of Ca2+ (0.9; 1.8; 3.6 and 7.2 mM/l) and norepinephrine (NE) (10−11, 10−9, 10−7, 10−5 g/ml) on the oxygen consumption and the contractile force of

Über die Wirkung von Prostaglandin E1 auf den Ca-Haushalt isolierter Meerschweinchenherzen

The stimulatory effect of PGE1 on different functions of isolated guinea-pig hearts (Langendorff method, Tyrode solution) was coupled with an increase in the rate of45Ca uptake from the perfusion medium, which seems to be related to the positive inotropic action of P GE1.

SOME FACTORS INFLUENCING THE RECOVERY OF ISOLATED MYOCARDIUM FROM ACUTE ANOXIA.

  • R. G. Penn
  • Biology
    British journal of pharmacology and chemotherapy
  • 1965
of energy transient periods of oxygen deprivation, capabilities of normal the isolated heart and isolated atria the Isolated hearts were perfused by the Langendorff technique with Locke solution at

Über die Dissoziation von Funktion und Stoffwechsel des isolierten Meerschweinchenherzens unter dem Einfluß von Phosphodiesterase-Hemmstoffen

The results do not support the concept of a common regulation of the mechanical and metabolic function of the heart muscle based solely on the cyclic-AMP-phosphorylase system.

Pharmacologic effects of theophylline in the newborn.

A Perception on Health Benefits of Coffee

Overall, with the available information, it can be concluded that the moderate consumption, corresponding to 3 to 4 cups/day with average strength is safer to human health.

References

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RELATION BETWEEN PHARMACOLOGIC AUGMENTATION OF CARDIAC CONTRACTILE FORCE AND THE ACTIVATION OF MYOCARDIAL GLYCOGEN PHOSPHORYLASE

It is not possible to decide which is the primary event in catecholamine action on the heart, the effect on phosphorylase or on the contractile mechanism, or whether both are concomitant phenomena with no immediate causal relationships.

The influence of enzyme inhibitors on the action of epinephrine on the frog's heart.

It has been concluded that this action of epinephrine is not dependent upon the functioning of either the cytochrome system or the tricarboxylic acid cycle and the locus of action is between the metabolically formed high-energy phosphate and the contractile process.

The effect of epinephrine and aminophylline on the phosphorylase activity of perfused contracting heart muscle.

Phosphorylases are present in heart muscle which are similar to phosphorylase a and b of skeletal muscle, and simultaneously with the increase in mechanical activity of the heart caused by epinephrine or aminophylline there appears to be a transformation of phosphory lase b to phosphate a.

Relation of biochemical effects of epinephrine to its muscular effects.

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  • Biology
    Pharmacological reviews
  • 1959
The actions of epinephrine on muscles are not dependent on either oxidative metabolism or on the energy produced from carbohydrate through the Embden-Meyerhof glycolytic pathway. Nonetheless, the

The action of epinephrine on the anaerobic or the iodoacetate-treated rat's diaphragm.

  • S. EllisS. Beckett
  • Biology, Medicine
    The Journal of pharmacology and experimental therapeutics
  • 1954
It is shown that an active non-glycolytic pathway for oxidative metabolism of glucose is not present in the rat diaphragm and the positive inotropic effect of epinephrine on the diphragm was present in either the anaerobic or the IAA-poisoned diaphagm.

Phosphorylase activity of heart muscle under various conditions affecting force of contraction.

It is concluded that, although in certain instances there may appear to be a parallelism between phosphorylase a activity and contractile force, a direct relationship does not obtain in all cases.

Factors affecting the activity of muscle phosphorylase b kinase.

A pyrex apparatus for the perfusion of the coronary circulation of mammalian hearts.

An all Pyrex apparatus for coronary perfusion by the technique of Langendorff has been described and its application to the hearts of six species has been discussed.