The incidentalome: a threat to genomic medicine.

@article{Kohane2006TheIA,
  title={The incidentalome: a threat to genomic medicine.},
  author={Isaac S. Kohane and Daniel R. Masys and Russ B. Altman},
  journal={JAMA},
  year={2006},
  volume={296 2},
  pages={
          212-5
        }
}
GENOMIC MEDICINE IS POISED TO OFFER A BROAD ARray of new genome-scale screening tests. However, these tests may lead to a phenomenon in which multiple abnormal genomic findings are discovered, analogous to the “incidentalomas” that are often discovered in radiological studies. If practitioners pursue these unexpected genomic findings without thought, there may be disastrous consequences. First, physicians will be overwhelmed by the complexity of pursuing unexpected genomic measurements. Second… 
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    Incidental variants are critical for genomics.
    Exome and Genome Sequencing and Parallels in Radiology: Searching for Patient-Centered Management of Incidental and Secondary Findings.
    An informatics approach to analyzing the incidentalome
    TLDR
    This work implemented for the first time a strategy that utilizes an a priori structured framework and a conservative threshold for selecting clinically relevant incidental findings and predicts that application of this strategy will facilitate pretest informed consent, laboratory analysis, and posttest return of results in a clinical context.
    Incidental Findings from Clinical Genome-Wide Sequencing: A Review
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    The practical considerations, ethical concerns and genetic counseling issues related to IF, with a particular focus on clinical genome-wide sequencing, are discussed.
    Management of Secondary Genomic Findings.
    Implications of the incidentalome for clinical pharmacogenomics.
    TLDR
    It is argued that provisional approaches to managing incidental findings may be implemented if necessary to allow benefits of pharmacogenomic testing to be realized in the clinical setting.
    The Human Genome Project, and recent advances in personalized genomics
    TLDR
    Several issues pertinent to health policy are discussed, namely: avoiding the conflation of genetics with biological determinism, resisting the "technological imperative”, due consideration of the organization of screening services, the need for professional education, as well as informed decision making and public understanding.
    Reconciling Opportunistic and Population Screening in Clinical Genomics
    Genetics professionals' perspectives on reporting incidental findings from clinical genome‐wide sequencing
    TLDR
    This is the first study to document the views of geneticists and genetic counselors in Canada towards the disclosure of IF, and represents a step towards evidence‐based guidelines for clinical genome‐wide sequencing investigations.
    Reporting Incidental Findings in Genomic Scale Clinical Sequencing-A Clinical Laboratory Perspective: A Report of the Association for Molecular Pathology.
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