The incidence of recurrence and hypothyroidism following treatment with antithyroid drugs, surgery or radioiodine in all patients with thyrotoxicosis in Malmö during the period 1970–1974

@article{Berglund1991TheIO,
  title={The incidence of recurrence and hypothyroidism following treatment with antithyroid drugs, surgery or radioiodine in all patients with thyrotoxicosis in Malm{\"o} during the period 1970–1974},
  author={J Berglund and Svend Borup Christensen and J. F. Dymling and Bengt Hallengren},
  journal={Journal of Internal Medicine},
  year={1991},
  volume={229}
}
Abstract. The incidence of recurrence and of hypothyroidism was determined in all new patients treated for thyrotoxicosis during the period 1970–1974 in an unselected, well‐defined urban population. A total of 309 patients were followed up for a median time period of 108 (1–192) months. There was a cumulative incidence of 51% recurrence in patients who were treated with antithyroid drugs for Graves' thyrotoxicosis, whereas after surgery or radioiodine treatment there were few recurrences, but… 

The incidence of recurrence and hypothyroidism after radioiodine treatment in patients with hyperthyroidism in Trakya, a mild iodine deficiency area, during the period 1991–2003

TLDR
Higher doses of radioiodine may be required to increase final treatment success in endemic goiter areas and dosimetry and calculated dose regimen would be required in all groups of patients instead of an FD concept.

Graves' hyperthyroidism: treatment with antithyroid drugs, surgery, or radioiodine--a prospective, randomized study. Thyroid Study Group.

TLDR
The increased risk of ophthalmopathy in patients with high serum T3 levels, especially when treated with iodine-131, and the relatively high frequency of relapse after treatment with antithyroid drugs are important factors to consider when selecting therapy for Graves' disease.

EVALUATION OF ANTI-THYROID DRUGS, RADIOACTIVE IODINE AND SURGERY IN PATIENTS WITH HYPERTHYROIDISM

TLDR
The first step in the treatment of Graves' is long-term treatment with anti-thyroid drugs, and in TMNG, radioactive iodine therapy is preferred, because of the high rate of complications effects for surgery.

Prolonged Treatment With Antithyroid Drugs: How Long to Treat Safely … Months, Years, or a Lifetime?

TLDR
A case where continuous use of antithyroid medications was safely and effectively employed for the treatment of hyperthyroidism over a period of 14 years in a patient who refused radioactive ablative therapy and surgery is described.

The cost effectiveness of treatment modalities for thyrotoxicosis in a U.K. center.

TLDR
The most cost-effective primary treatment modality for thyrotoxicosis is radioiodine, according to this study, which is also the most effective treatment for Graves' disease.

The long-term outcome of treatment for Graves' hyperthyroidism.

TLDR
A patient selecting ATD therapy as the initial approach in the treatment of Graves' hyperthyroidism should be informed that they have only a 50.3% chance of ultimately avoiding ablative treatment and only a 40%chance of eventually being euthyroid without thyroid medication.

Long-term Prognosis of Patients Treated with Radioactive Iodine for Hyperthyroidism

TLDR
A population-based cohort study was conducted among all 2793 hyperthyroid patients treated with RAI at the Tampere University Hospital between 1965 and 2002, and 2793 ageand gender-matched reference subjects, finding that administration of a single dose of RAI resulted in the control ofhyperthyroidism in 75% of patients in both etiologic groups.

Thyrotoxicosis in childhood.

TLDR
Whether T4 addition has a beneficial effect on the risk of recurrence still needs to be proven in adults outside Japan (8), and no data exist on the recurrence rate in children after T4 supplementation.

Long-term prognosis after medical treatment of Graves' disease in a northern Swedish population 2000-2010.

TLDR
A long-term remission of 56.5%, in an iodine-sufficient area where ATD is offered to most patients in the real world of central and district hospitals, is higher than in most studies.

References

SHOWING 1-10 OF 58 REFERENCES

Long-term observation of thyroid function after surgical treatment of thyrotoxicosis.

TLDR
It is concluded that subtotal thyroidectomy preceded by short-term antithyroid drug therapy supplemented ultimately with iodine offers significant advantages in the management of thyrotoxicosis by rendering 85% of patients euthyroid on long-term surveillance.

LONG‐TERM RESULTS FROM GRADED LOW DOSE RADIOACTIVE IODINE THERAPY FOR THYROTOXICOSIS

An analysis has been made of the results of treatment in a series of 261 consecutive patients given graded low dose radioactive iodine therapy for thyrotoxicosis. Of these patients, 140 (54%) became

ANTITHYROID DRUGS IN THE TREATMENT OF HYPERTHYROIDISM OF Graves' DISEASE: LONG‐TERM FOLLOW‐UP OF 434 PATIENTS

TLDR
A standard format should be adopted for the analysis and reporting of follow‐up studies, based on actuarial methods of estimating the cumulative proportion with recurrences or other events, to facilitate comparisons between different centres.

Prediction of Hypothyroidism after Partial Thyroidectomy for Thyrotoxicosis

TLDR
The ability to assess thyroid status early after surgery is of some merit in the long-term supervision of the postoperative thyrotoxic patient, and in this respect surgical treatment seems to have some advantage over radioiodine therapy.

An evaluation of several prognostic factors in the surgical treatment for thyrotoxicosis.

TLDR
Although the precise mechanism of remission by surgical ablation of the thyroid has not been clarified, surgical treatment is an effective and safe procedure which controls the condition of the patient with thyrotoxicosis and the optimal weight of the remnant thyroid should be approximately 10 grams.

Long-term follow-up study of compensated low-dose 131I therapy for Graves' disease.

TLDR
It is suggested that it will be difficult to modify therapy with 131I alone to produce both early control of thyrotoxicosis and a low incidence of hypothyroidism.

Current treatment of Graves' disease.

Hypothyroidism as a late sequela in patient with Graves' disease treated with antithyroid agents.

TLDR
It is concluded that progressive failure of thyroid function is a common occurence in long-standing Graves' disease, and it is suggested that this results from concomitant chronic thyroiditis.

Hyperthyroidism in the land of Graves: results of treatment by surgery, radio-iodine and carbimazole in 837 cases.

A review of the outcome of treatment by subtotal thyroidectomy, radio-iodine and carbimazole of 837 patients with hyperthyroidism seen consecutively over the period 1954--78 inclusive is presented.

The mechanism of spontaneous hypothyroidism in patients with Graves' disease after antithyroid drug treatment.

TLDR
The natural course of Graves' disease results in hypothyroidism in up to 20% of patients previously treated with antithyroid drugs, although autoimmune destruction of thyroid tissue has been proposed, and the appearance of antibodies that block TSH stimulation may be another.
...