The incidence of prenatal brain injury

@article{Squier1991TheIO,
  title={The incidence of prenatal brain injury},
  author={Marian V. Squier and Jean W. Keeling},
  journal={Neuropathology and Applied Neurobiology},
  year={1991},
  volume={17}
}
  • M. Squier, J. Keeling
  • Published 1 February 1991
  • Medicine, Psychology
  • Neuropathology and Applied Neurobiology
Recent epidemiological studies have shown that cerebral palsy is only rarely associated with birth asphyxia and that there may be more important causative factors in the prenatal period. For this reason a series of 165 brains of infants who were stillborn or died in the early neonatal period was examined in order to identify the incidence and nature of prenatal brain damage. 
Prenatally Diagnosed Fetal Brain Injuries with Known Antenatal Etiologies
TLDR
This work presents 4 cases of antenatally diagnosed brain injury with known and unusual etiology, characterized by multiple necrotic foci of the white matter found most frequently adjacent to the lateral ventricles.
The Scottish Perinatal Neuropathology Study—clinicopathological correlation in stillbirths
TLDR
The neuropathology of fetuses dying before birth is examined to determine the timing of any brain damage seen and to ascertain clinical associations of pre‐existing brain damage.
Brain damage and axonal injury in a Scottish cohort of neonatal deaths.
TLDR
The presence together of recent and older damage in individual brains suggests that there is an ongoing neuronal response to cerebral insults in surviving infants, and betaAPP is a useful marker of white matter damage in the neonatal brain.
Can neurological injury be timed?
TLDR
Limitations exist for all modalities, however, imaging studies, electroencephalograms and pathologic examination provide the most useful information.
PRENATAL BRAIN DAMAGE AND PLACENTAL INFARCTION –AN AUTOPSY STUDY
TLDR
It was concluded that placental infarcts are commonly associated with prenatal cerebral ischaemie lesions, particularly in stillborn infants with major cerebral malformations.
Neuropathology associated with stillbirth.
TLDR
A variety of abnormalities are found in the brains of stillborns, the most common including cerebral white matter necrosis (periventricular leukomalacia) or gliosis, germinal matrix or intraventricular hemorrhage, cerebral infarcts, pontosubicular necrosis, and spinal cord or brainstem necrosis.
Acquired Diseases of the Nervous System
TLDR
This chapter describes the more common acquired conditions likely to be encountered in routine postmortem examinations of neonates and fetuses.
The Scottish perinatal neuropathology study: clinicopathological correlation in early neonatal deaths
TLDR
In a large proportion of neonatal deaths, brain injury predates the onset of labour, more common in infants born in an asphyxiated condition.
The Neuropathology
TLDR
Although HI1 and trauma predominate in causing haeniorrhage, other predisposing factors include: coagulopathies, iatrogenic causes such as extracorporeal membrane oxygenation (ECMO), infections, vascular malformations and turnours.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 31 REFERENCES
Brain injury and intrauterine death.
Fetal encephalopathies of circulatory origin.
  • J. Larroche
  • Medicine, Psychology
    Biology of the neonate
  • 1986
TLDR
With generalized ultrasonography of the fetus, the lesions can be detected in utero and subsequent neurological handicaps of the infants will no longer be attributed to difficult labor and birth.
Intrapartum asphyxia and cerebral palsy.
TLDR
To attribute cerebral palsy to prior asphyxia with reasonable certainty, there must be evidence that a substantial hypoxic injury occurred and that a sequence of events ensued which would prove the clinical impact of that hypoxic insult.
Neuropathologic documentation of prenatal brain damage.
TLDR
Unless fetal/maternal abnormalities in late gestation are identified and corrected, improved neonatal care will increase survival for prenatally damaged infants and the incidence of cerebral palsy may rise.
Antecedents of cerebral palsy. Multivariate analysis of risk.
Abstract We examined prenatal and perinatal factors predicting cerebral palsy, using multivariate analysis to investigate which factors were most important and the proportion of cases for which they
Periventricular leukomalacia of infancy. A form of neonatal anoxic encephalopathy.
TLDR
A unique disease of cerebral white matter which has been encountered with great frequency among infants who died at the Children's Hospital Medical Center, Boston is drawn attention.
Antenatal origin of neurologic damage in newborn infants. II. Multiple gestations.
...
1
2
3
4
...