The incidence of medulloblastomas and primitive neurectodermal tumours in adults and children

@article{Smoll2012TheIO,
  title={The incidence of medulloblastomas and primitive neurectodermal tumours in adults and children},
  author={Nicolas Roydon Smoll and Katharine J. Drummond},
  journal={Journal of Clinical Neuroscience},
  year={2012},
  volume={19},
  pages={1541-1544}
}
Medulloblastomas (MB) and primitive neurectodermal tumours (PNET) are known to affect children more than adults. To estimate the magnitude of the differences between the incidence of adults and children, the incidence rates, ratios and time trends of MB and PNET in children and adults are measured using data from the Surveillance, Epidemiology and End-Results (SEER) database. Between 1973 and 2007 in the SEER 9 registries, 1372 people were diagnosed with a MB and 530 with a PNET. The overall… Expand
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References

SHOWING 1-10 OF 14 REFERENCES
Incidence and trends in pediatric malignancies medulloblastoma/primitive neuroectodermal tumor: a SEER update. Surveillance Epidemiology and End Results.
TLDR
It is found that medulloblastoma and PNET are histologically identical and have similar epidemiologic profiles, and future studies should provide analyses that combine these entities. Expand
Is medulloblastoma the same tumor in children and adults?
TLDR
Some phenotypic differences between childhood and adult medulloblastoma exist, but do not support a substantially different course of the disease. Expand
Epidemiology of adult medulloblastoma
TLDR
The epidemiological data are consistent with an embryonal origin of medulloblastoma, which is higher than that generally assumed, and indicates that the occurrence of this embryonal tumor in adult age is relevant. Expand
Medulloblastoma in childhood: an epidemiological study.
TLDR
Survival probability was statistically significantly better in the years 1968 to 1977 than in previous decades, in part due to fewer autopsy diagnoses and lowered operative mortality, but also due to a decreased mortality rate in children several years after diagnosis. Expand
Relative survival of childhood and adult medulloblastomas and primitive neuroectodermal tumors (PNETs)
TLDR
The author investigated the impact of medulloblastomas/primitive neuroectodermal tumors (PNETs) on the US population with a focus on age differences. Expand
Maternal Diet During Pregnancy and its Association with Medulloblastoma in Children: A Children’s Oncology Group Study (United States)
TLDR
The results suggest that some aspects of diet are worthy of further research, and cured meats were not associated with medulloblastoma/PNET, in contrast to other childhood brain tumors. Expand
Prediction of central nervous system embryonal tumour outcome based on gene expression
TLDR
It is demonstrated that medulloblastomas are molecularly distinct from other brain tumours including primitive neuroectodermal tumours, atypical teratoid/rhabdoid tumours (AT/RTs) and malignant gliomas, and it is shown that the clinical outcome of children with medullOBlastomas is highly predictable on the basis of the gene expression profiles of their tumours at diagnosis. Expand
The Genetic Landscape of the Childhood Cancer Medulloblastoma
TLDR
Key differences between the genetic landscapes of adult and childhood cancers are demonstrated, dysregulation of developmental pathways as an important mechanism underlying MBs is highlighted, and a role for a specific type of histone methylation in human tumorigenesis is identified. Expand
Maternal Supplement, Micronutrient, and Cured Meat Intake during Pregnancy and Risk of Medulloblastoma during Childhood: A Children's Oncology Group Study
TLDR
The results of the study add to the evidence of a protective role for multivitamins, suggest a possible role for micronutrients early in pregnancy, and generally do not support an association between cured meats and medulloblastoma/PNET. Expand
A phase II study of preradiotherapy chemotherapy followed by hyperfractionated radiotherapy for newly diagnosed high-risk medulloblastoma/primitive neuroectodermal tumor: a report from the Children's Oncology Group (CCG 9931).
TLDR
The feasibility of this intensive multimodality protocol was confirmed, and response to pre-RT CHT did not impact on survival, and survival data from this protocol can not be compared with data from other studies, given the protocol design. Expand
...
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