The incidence and possible relevance of Y-linked microdeletions in babies born after intracytoplasmic sperm injection and their infertile fathers.

@article{KentFirst1996TheIA,
  title={The incidence and possible relevance of Y-linked microdeletions in babies born after intracytoplasmic sperm injection and their infertile fathers.},
  author={Marijo G. Kent-First and S Kol and Ariege Muallem and Rivka Ofir and Dorit Manor and Shraga Blazer and Neal L. First and Joseph Itskovitz-Eldor},
  journal={Molecular human reproduction},
  year={1996},
  volume={2 12},
  pages={943-50}
}
Microdeletions linked to deletion intervals 5 and 6 of the Y chromosome have been associated with male factor infertility. Members from at least two gene families lie in the region containing azoospermia factor (AZF), namely YRRM and DAZ. With the advent of intracytoplasmic sperm injection (ICSI), it is possible for men with severe male factor infertility to produce a child. The genetic consequences of such a procedure have been questioned. This report describes the first study of a population… CONTINUE READING
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